CARISMED promotes the uptake of results achieved by 3 ongoing ENI CBC MED projects to develop policies for improving sustainability and integrating innovation into the urban settings of Mediterranean cities, through the capitalization of circular economy (CE) and creative approaches. A great deal of experience in re-setting the existing environment will be provided by these projects through refurbishment and re-using underutilized or abandoned urban stock. Towards a more sustainable and smart urban development, a low-cost Adaptive Reuse Strategy will use MAIA-TAQA innovation practices and interlinks with policy-makers, and INNOMED-UP model for CE procedures within Cultural Creative Industry (CCI) SMEs. CE supply chain will address urban challenges while creating business opportunities for SMEs by using INNOMED-UP model and SME4SMARTCITIES smart tools and techniques through ‘ready to deploy’ solutions. Cooperation agreements among cluster members will be further built up to enhance collaborative innovation schemes based on MAIA-TAQA policy instruments, SME4SMARTCITIES framework for collaboration between the public and private sector, and INNOMED-UP framework for CCI SMEs clustering. Finally, the project will promote innovative methodologies for re-setting the built environment in Mediterranean cities by developing a toolkit and guide on upcycling buildings and areas through CCI SMEs clustering.